We examine here the effects of recurrent vaccination and waning immunity on the establishment of an endemic equilibrium in a population. An individual-based model that incorporates memory effects for transmission rate during infection and subsequent immunity, is introduced, considering stochasticity at the individual level. By letting the population size to go to infinity, we derive a set of equations describing the large scale behavior of the epidemic. The analysis of the model’s equilibria reveals a criterion for the existence of an endemic equilibrium, which depends on the rate of immunity loss and the distribution of time between booster doses. The outcome of a vaccination policy in this context is influenced by the efficiency of the vaccine in blocking transmissions and the distribution pattern of booster doses within the population. Strategies with evenly spaced booster shots at the individual level prove to be more effective in preventing disease spread compared to irregularly spaced boosters, as longer intervals without vaccination increase susceptibility and facilitate more efficient disease transmission. We provide an expression for the critical fraction of the population required to adhere to the vaccination policy in order to eradicate the disease, that resembles a well-known threshold for preventing an endemic state with an imperfect vaccine. We also investigate the consequences of unequal vaccine access in a population and prove that, under reasonable assumptions fair vaccine allocation is the optimal strategy to prevent endemicity.
We examine here the effects of recurrent vaccination and waning immunity on the establishment of an endemic equilibrium in a population. An individual-based model that incorporates memory effects for transmission rate during infection and subsequent immunity, is introduced, considering stochasticity at the individual level. By letting the population size to go to infinity, we derive a set of equations describing the large scale behavior of the epidemic. The analysis of the model’s equilibria reveals a criterion for the existence of an endemic equilibrium, which depends on the rate of immunity loss and the distribution of time between booster doses. The outcome of a vaccination policy in this context is influenced by the efficiency of the vaccine in blocking transmissions and the distribution pattern of booster doses within the population. Strategies with evenly spaced booster shots at the individual level prove to be more effective in preventing disease spread compared to irregularly spaced boosters, as longer intervals without vaccination increase susceptibility and facilitate more efficient disease transmission. We provide an expression for the critical fraction of the population required to adhere to the vaccination policy in order to eradicate the disease, that resembles a well-known threshold for preventing an endemic state with an imperfect vaccine. We also investigate the consequences of unequal vaccine access in a population and prove that, under reasonable assumptions fair vaccine allocation is the optimal strategy to prevent endemicity.
After a couple of days in London, I will spend some time in Oxford, working with Félix Foutel-Rodier, who was last year with us in Montréal as a postdoc fellow, working on mathematical models of pandemic (we plan to finalize our paper, and upload it on arxiv very soon)
"sendo l'intento mio scrivere cosa utile a chi la intende…"
