Consider a (simple) Poisson regression . Given a sample where , the goal is to derive a 95% confidence interval for given , where is the prediction. Hence, we want to derive a confidence interval for the prediction, not the potential observation, i.e. the dot on the graph below

> r=glm(dist~speed,data=cars,family=poisson)
> P=predict(r,type="response",
+ newdata=data.frame(speed=seq(-1,35,by=.2)))
> plot(cars,xlim=c(0,31),ylim=c(0,170))
> abline(v=30,lty=2)
> lines(seq(-1,35,by=.2),P,lwd=2,col="red")
> P0=predict(r,type="response",se.fit=TRUE,
+ newdata=data.frame(speed=30))
> points(30,P1$fit,pch=4,lwd=3)

i.e.

Let denote the maximum likelihood estimator of . Then

where is Fisher information of (from standard maximum likelihood theory). Recall that

where computation of those values is based on the following calculations

In the case of the log-Poisson regression

Let us get back to our initial problem.

• confidence interval for the linear combination

A first idea to get a confidence interval for is to get a confidence interval for (by taking exponential values of bounds, since the exponential is a monotone function). Asymptotically, we know that

thus, an approximation for the variance matrix of will be based on , obtained by plugging estimators of the parameters.
Then, since as an asymptotic multivariate distribution, any linear combination of the parameters will also be normal, i.e.
has a normal distribution, centered on , with variance where is the variance of . All those quantities can be easily computed. First, we can get the variance of the estimators

> i1=sum(predict(reg,type="response"))
> i2=sum(cars$speed*predict(reg,type="response"))
> i3=sum(cars$speed^2*predict(reg,type="response"))
> I=matrix(c(i1,i2,i2,i3),2,2)
> V=solve(I)

Hence, if we compare with the output of the regression,

> summary(reg)$cov.unscaled
(Intercept)         speed
(Intercept)  0.0066870446 -3.474479e-04
speed       -0.0003474479  1.940302e-05
> V
[,1]          [,2]
[1,]  0.0066871228 -3.474515e-04
[2,] -0.0003474515  1.940318e-05

Based on those values, it is easy to derive the standard deviation for the linear combination,

> x=30
> P2=predict(r,type="link",se.fit=TRUE,
+ newdata=data.frame(speed=x))
> P2
$fit
1
5.046034

$se.fit
[1] 0.05747075

$residual.scale
[1] 1

> sqrt(V[1,1]+2*x*V[2,1]+x^2*V[2,2])
[1] 0.05747084
> sqrt(t(c(1,x))%*%V%*%c(1,x))
[,1]
[1,] 0.05747084

And once we have the standard deviation, and normality (at least asymptotically), confidence intervals are derived, and then, taking the exponential of the bounds, we get confidence interval

> segments(30,exp(P2$fit-1.96*P2$se.fit),
+ 30,exp(P2$fit+1.96*P2$se.fit),col="blue",lwd=3)

Based on that technique, confidence intervals are no longer centered on the prediction. But who cares ?

> estmean=t(c(1,x))%*%coef(reg)
> var=t(c(1,x))%*%summary(reg)$cov.unscaled%*%c(1,x)
> library(msm)
> deltamethod (~ exp(x1), estmean, var)
[1] 8.931232
> P1=predict(r,type="response",se.fit=TRUE,
+ newdata=data.frame(speed=30))
> P1
$fit
1
155.4048

$se.fit
1
8.931232

$residual.scale
[1] 1

> segments(30,P1$fit-1.96*P1$se.fit,30,
+ P1$fit+1.96*P1$se.fit,col="blue",lwd=3)

> exp(P2$fit-1.96*P2$se.fit)
1
138.8495
> P1$fit-1.96*P1$se.fit
1
137.8996
> exp(P2$fit+1.96*P2$se.fit)
1
173.9341
> P1$fit+1.96*P1$se.fit
1
172.9101